Column #320    October 22, 2021Original Antigenic Sin

This original sin isn’t about religion, it’s about how immune systems work and don’t work. In fact, it could be about how a vaccine can end up killing you. Even the CDC and NIH are fully aware of the phrase “Original Antigenic Sin.” It’s not anti-vaxxer radicalization. It has been discussed in scientific papers for decades. It’s about the way vaccines train the immune system. You’ll find many references to this topic in medical journals and even on the CDC’s own website.1

For the scientific explanation I’ll refer to a report in the September 2017 Journal of Autoimmunity, Volume 83, titled “Original antigenic sin: A comprehensive review.” Here is the Abstract word for word:2

“The concept of ‘original antigenic sin’ was first proposed by Thomas Francis, Jr. in 1960. This phenomenon has the potential to rewrite what we understand about how the immune system responds to infections and its mechanistic implications on how vaccines should be designed.

“Antigenic sin has been demonstrated to occur in several infectious diseases in both animals and humans, including human influenza infection and dengue fever. The basis of ‘original antigenic sin’ requires immunological memory, and our immune system ability to autocorrect. In the context of viral infections, it is expected that if we are exposed to a native strain of a pathogen, we should be able to mount a secondary immune response on subsequent exposure to the same pathogen.

“‘Original antigenic sin’ will not contradict this well-established immunological process, as long as the subsequent infectious antigen is identical to the original one. But ‘original antigenic sin’ implies that when the epitope [point of antibody attachment] varies slightly, then the immune system relies on memory of the earlier infection, rather than mount another primary or secondary response to the new epitope which would allow faster and stronger responses. The result is that the immunological response may be inadequate against the new strain, because the immune system does not adapt and instead relies on its memory to mount a response.

“In the case of vaccines, if we only immunize to a single strain or epitope, and if that strain/epitope changes over time, then the immune system is unable to mount an accurate secondary response. In addition, depending of the first viral exposure the secondary immune response can result in an antibody-dependent enhancement of the disease or at the opposite, it could induce anergy [lack of response]. Both of them triggering loss of pathogen control and inducing aberrant clinical consequences.”

Here’s an example of an “aberrant clinical consequence.” It’s from a September 5, 2021 post by Jesse Santiano, M.D. titled “What is Antibody-Dependent Enhancement and Why Should You Care?”3

“Antibody-Dependent Enhancement, (ADE) is a phenomenon observed in animals during vaccine development against the coronaviruses and measles, respiratory syncytial virus, and dengue viruses previously.
“In ADE, the inoculated animals develop the antibodies, but with time, the neutralizing antibodies decrease. When the animals were exposed to a wild-type coronavirus (to test vaccine effectiveness), instead of being protected the animals developed severe infections and died.”

Does this explain the government’s panic surrounding the mandates for boosters? If all this is true, then should we want to be vaccinated with the narrowly targeted experimental vaccines in the first place? It also brings into question whether or not it’s prudent for children to get vaccinated. First of all, children rarely get sick when they do catch the virus and deaths are extremely rare. Secondly, if children get the jab, which quickly loses its effectiveness, then would that make children far more vulnerable to a mutated covid infection?

There’s still a lot to learn about the new mRNA vaccines. They certainly haven’t been held to the same safety and effectiveness standards as all other established vaccines. Unfortunately, more news about the vaccines comes out daily and it’s not all wine and roses. Yesterday a reader sent me a link to a discussion between Joe Rogan and Alex Berenson about the soaring case rate for vaccinated people in the United Kingdom.4

My concerns for the vaccine remain. That’s why I rely more than ever on enhancing my own natural immunity with diet, rest, exercise, meditation, and getting my body’s balance of Omega-6 to Omega-3 essential fatty acids as close to 1:1 as possible.5

To your health.

Ted Slanker

Ted Slanker has been reporting on the fundamentals of nutritional research in publications, television and radio appearances, and at conferences since 1999. He condenses complex studies into the basics required for health and well-being. His eBook, The Real Diet of Man, is available online.

Don't miss these links for additional reading:

1. Pages Mentioning “Original Antigenic Sin” on the CDC Website

2. Original Antigenic Sin: a Comprehensive Review by Anup Vattia, et al. from Journal of Autoimmunity

3. What is Antibody-Dependent Enhancement and Why Should You Care by Jesse Santiano, M.D.

4. A Discussion about the United Kingdon’s Failing COVID-19 Jab by Joe Rogan (podcast host/comedian) and Alex Berenson (journalist and author)

5. Protecting Immunity by Ted Slanker

Image Link
T Cell Immunity to Dengue Virus and Implications for Vaccine Design by Laura Rivino from Research Gate